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the following medicines may reduce the removal of methylprednisolone from the body and so may increase its effects or side effects .

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methylprednisolone, like many cyp3a4 substrates, may also be a substrate for atp-binding cassette abc transport protein p-glycoprotein, influencing tissue distribution and interactions with other medicines.

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methylprednisolone major patients receiving tacrolimus and systemic corticosteroids concomitantly should be carefully monitored for alterations in tacrolimus whole blood concentrations.

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exceeding prednisolone in anti-inflammatory potency and having even less tendency than prednisolone to induce sodium and water retention, methylprednisolone offers the advantage over older corticosteroids of affording equally satisfactory anti-inflammatory effect with the use of lower doses and with an enhanced split between anti-inflammatory and mineralocorticoid activities.

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prednisolone sodium phosphate is very soluble in water, and is therefore less likely to cause local gastric irritation than prednisolone alcohol, which is only slightly soluble.

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